Only Trulance is thought to replicate the pH-sensitivity of naturally
occurring uroguanylin1-4

With the exception of a single amino acid substitution for greater binding affinity, Trulance is structurally identical to human uroguanylin4,5

Trulance replicates the activity of human uroguanylin4

  1. Uroguanylin is naturally secreted after ingestion6,7
  2. Human uroguanylin activates guanylate cyclase-C (GC-C) receptors in a pH-sensitive manner, primarily in the small intestine4
  3. GC-C activation increases cyclic guanosine monophosphate (cGMP) levels, stimulating fluid movement into the intestinal lumen1
  4. Regulation of fluid and electrolyte homeostasis in the small intestine facilitates bowel movements6,8
  5. Uroguanylin modulates its activity within the changing pH environment of the intestine, stimulating fluid secretion and maintaining stool consistency necessary for regular bowel function1,9

Based on pre-clinical studies. Clinical relevance of this data has not been established.