Only Trulance is thought to replicate the pH-sensitivity of uroguanylin—a naturally occurring peptide1-4

With the exception of a single amino acid, Trulance is structurally identical to human uroguanylin4,5

Uroguanylin activity modulates within the changing pH environment of the intestines, coinciding with areas of fluid secretion1,6,7

1ACTIVATES GC-C receptors in a pH-sensitive manner

2Increases cGMP and regulates electrolyte homeostasis

3Stimulates fluid secretion and facilitates bowel movements

Uroguanylin stimulates fluid secretion, thereby maintaining stool consistency necessary for regular bowel function1,6

Based on pre-clinical studies. Clinical relevance of this data has not been established.